Volume 122, Issue 5 p. 717-720
Article
Free Access

Correlation of Neural Cell Adhesion Molecules with Perineural Spread of Squamous Cell Carcinoma of the Head and Neck

Dr Emre Vural MD

Corresponding Author

Dr Emre Vural MD

Departments of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas

Reprint requests: Emre Vural, MD, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 543, Little Rock, AR 72205.Search for more papers by this author
Dr James Hutcheson MD

Dr James Hutcheson MD

Departments of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas

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Dr Soheila Korourian MD

Dr Soheila Korourian MD

Departments of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas

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Dr Sofia Kechelava PhD

Dr Sofia Kechelava PhD

Departments of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas

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Dr Ehab Hanna MD

Dr Ehab Hanna MD

Departments of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas

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First published: 01 September 2016
Citations: 2

Presented at the Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery, New Orleans, LA, September 26-29, 1999

Abstract

Perineural spread (PNS) is a poor prognostic factor associated with increased risk of local recurrence and nodal metastasis and reduced survival of patients with squamous cell carcinoma of the head and neck (SCCHN). There is some evidence to indicate that neural cell adhesion molecules (NCAMs) may play a role in PNS of a variety of tumor types. We performed this study to investigate whether NCAM expression can be used as a predictor of PNS in SCCHN. The surgical specimens of 66 patients with SCCHN were evaluated with monoclonal IgG antibody immunoperoxidase staining for NCAM. Of the 41 specimens with PNS, 38 (93%) showed evidence of NCAM expression. In contrast, only 9 specimens (36%) without PNS expressed NCAMs. The difference in NCAM expression between the study and control groups was statistically significant (P > 0.01).